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Individualize BP-lowering therapy and treatment targets in people with frailty, high risk of falls, very

 limited life expectancy, or symptomatic postural hypotension.

Treatments that delay progression of CKD with a strong evidence base include RASi and SGLT2i. In

 people with CKD and heart failure, SGLT2i confer benefits irrespective of albuminuria.

Initial dips in eGFR are expected following initiation of hemodynamically active therapies, including both

 RASI and SGLT2i. GFR reductions of ≥30% from baseline exceed the expected variability and warrant

 evaluation.

CKD is not a contraindication to an invasive strategy for people with acute or unstable heart disease.

 Imaging studies are not necessarily contraindicated in people with CKD and the risks and benefits should

 be determined on an individual basis.

  • A substance is more radiopaque if it contains atoms of high atomic number (AN) such as calcium, iodine, barium, or lead.
  • Bone, which contains calcium (AN 20), is more radiopaque than soft tissue, which is made up mostly of carbon (AN 6), hydrogen (AN 1), and oxygen (AN 8). 
  • Iodine (AN 53) is the key constituent of radiocontrast material and lead (AN 82) is an effective barrier to x-rays.


The eye is very complex and contains various tissues and structures that work together to provide vision.

 Eye problems can range from benign, self-resolving processes to malignant, and possibly metastatic

 tumors. Eye disorders can be caused by various factors, resulting in various signs and symptoms. They

 can be as trivial as minor irritation or pain all the way to blurred vision or blindness. Strabismus is a

 visual disorder in which the eyes are misaligned and point in different directions. When the eyes are

 misaligned, typically one eye will fixate on objects of interest while the other eye turns in (esotropia), out

 (exotropia), down (hypotropia), or up (hypertropia).



  • Monitor for changes in BP, serum creatinine, & serum K+ within 2–4 weeks of initiation or increase in the dose of an ACEi or ARB. 
  • Continue ACEi or ARB therapy unless serum creatinine rises by > 30% within 4 weeks following initiation of treatment or an increase in dose.
  • FDA recommends, metformin should NOT be used with serum creatinine ≥ 1.5 mg/dl in men & ≥ 1.4 mg/dl in women or with decreased creatinine clearance in people > 80.
  • Recommended is treating patients with T2D, CKD, & an eGFR ≥ 30 ml/min per 1.73 m2 with metformin.


ADA/KDIGO Consensus Statements:


All patients with Type 1 diabetes or Type 2 diabetes and CKD should be treated with a

comprehensive plan, outlined and agreed by health care professionals and the patient 

together, to optimize nutrition, exercise, smoking cessation, and weight, upon which are

layered evidence-based pharmacologic therapies  aimed at preserving organ function and 

other therapies selected to attain intermediate targets for glycemia, blood pressure, and lipids.


Myocardial Infarction:

Classified into 5 types based on etiology and circumstances:

  • Type 1: Spontaneous MI caused by ischemia due to a primary coronary event (eg, plaque rupture, erosion, or fissuring; coronary dissection).
  • Type 2: Ischemia due to increased oxygen demand (eg, hypertension), or decreased supply (eg, coronary artery spasm or embolism, arrhythmia, hypotension).
  • Type 3: Related to sudden unexpected cardiac death. 
  • Type 4a: Associated with percutaneous coronary intervention (signs and symptoms of myocardial infarction with cTn values > 5 × 99th percentile URL). 
  • Type 4b: Associated with documented stent thrombosis. 
  • Type 5: Associated with coronary artery bypass grafting (signs and symptoms of myocardial infarction with cTn values > 10 × 99th percentile URL).

Infarct location

  • Right ventricular infarction usually results from obstruction of the right coronary or a dominant left circumflex artery; it is characterized by high RV filling pressure, often with severe tricuspid regurgitation and reduced cardiac output.
  • An inferoposterior infarction causes some degree of RV dysfunction in about half of patients and causes hemodynamic abnormality in 10 to 15%. RV dysfunction should be considered in any patient who has inferoposterior infarction and elevated jugular venous pressure with hypotension or shock. RV infarction complicating LV infarction significantly increases mortality risk.
  • Anterior infarcts tend to be larger and result in a worse prognosis than inferoposterior infarcts. They are usually due to left coronary artery obstruction, especially in the anterior descending artery; inferoposterior infarcts reflect right coronary or dominant left circumflex artery obstruction.

Legend says that Cholangitis was first defined in 1877 by Jean-Martin Charcot, at which time the

 pathognomonic triad of fever, right upper quadrant pain, and jaundice was described. Today, cholangitis is

 defined as the presence of increased hepatic intraductal pressure with a concurrent infection of the

 obstructed bile.

Chole: Derived from the Greek word “cholē” meaning bile.

Angio: Comes from the Greek “angeion” meaning vessel.

Cholangitis: Bacterial infection of the biliary tree.


The pathogens identified as causative agents of acute ascending cholangitis are gram-negative and

 anaerobic organisms, the most common including Escherichia coli, Klebsiella, Enterobacter,

 Pseudomonas, and Citrobacter.  

Iatrogenic introduction of bacteria commonly occurs post- ERCP in individuals with biliary obstruction.

Charcot triad has a high specificity (95.9%), while sensitivity is low (26.4%).

Tokyo guidelines (2018) have a sensitivity of 100% and specificity of 87.4%.

 

 


The term ‘pseudo’ means ‘false’, ‘pretended’, ‘unreal’, or ‘sham’. Likely to be of Greek

origin, pseudes means false. There are a number of ‘pseudo’ terms and syndromes that we see

in the common practice. Even though the meaning of pseudo is unreal or sham, however

several medical conditions/ syndromes are true entities as described above.


"D" sign:
In a physiologically normal heart, LV pressure > RV pressure. When viewing heart in a parasternal short

 axis during systole the LV maintains a circular appearance, bowing the intraventricular septum into the

 right ventricle. A D-shaped left ventricle or flattening of the interventricular septum with a D-shaped

 configuration is a feature described with significant RV overload / right heart strain such as that occurring

 with complications of a sizable pulmonary embolic event.

McConnell's sign:

An echocardiographic finding of segmental right ventricular wall‐motion abnormality with apical sparing,

 is highly specific in acute pulmonary embolism and may guide rapid intervention when other testing is

 not feasible.

 

Thyroid storm is a rare and life-threatening condition characterized by an acute exacerbation of

 thyrotoxicosis (elevated free triiodothyronine or free thyroxine and suppressed thyrotropin) with severe

 clinical symptoms. It often results in multiorgan failure involving one or more organ systems such as the

 central nervous, cardiac, hepatic, pulmonary, respiratory, digestive, and gastrointestinal excretory

 systems.


Specific Strategic Steps for Treatment
  • Therapy to control increased adrenergic tone: Beta-blocker
  • Therapy to reduce thyroid hormone synthesis: Thionamide
  • Therapy to reduce the release of thyroid hormone: Iodine solution
  • Therapy to block peripheral conversion of T4 to T3: Iodinated radiocontrast agent, glucocorticoid, PTU, propranolol
  • Therapy to reduce enterohepatic recycling of thyroid hormone: Bile acid sequestrant

     

Theophilus Protospatharius, a seventh-century physician who wrote the first manuscript focused

 exclusively on urine called "De Urinis", determined heating urine would precipitate proteins,

 documenting proteinuria as a disease state. French scholar named Gilles de Corbeil (12th century)

 classified 20 different types of urine, recording differences in urine sediment and color and introduced the

 "matula," a glass vessel in which a physician could assess color, consistency, and clarity.


Following includes the complete analysis of urine:

Visual exam
• Color. 
• Clarity
Dipstick test
• Acidity (urine pH). 
• Bilirubin. 
• Blood (hemoglobin). 
• Glucose. 
• Ketones
• Leukocyte esterase.
• Nitrites. 
• Protein
• Urine specific gravity test. 
Microscopic exam
• Crystals. 
• Epithelial cells. 
• Bacteria, yeast and parasites (infections). 
• Red blood cells (RBC). 
• Urinary casts: 
• White blood cells 


Fractional excretion of Sodium (FE Na).
  • [(U Na x P Cr) / (P Na x U Cr)] x 100
  • U = Urine, P = Plasma, Cr = Creatinine, Na = Sodium.
  • Re-absorption and filtration accounted (Both).
  • Should not be used with normal renal function.

Acute Kidney Injury (AKI)
  • FE Na < 1%
  • Urine sodium < 20 mEq/L.

Acute Tubular Necrosis (ATN)
  • FE Na > 2%
  • Urine sodium > 40 mEq/L.


Hypoglycemia In Diabetics

Type 1 DM/Type 2 DM,
Kidney disease: insulin not cleared out of circulation well.
Medications for Diabetic.

More frequently:
Meglitinides, 
Sulfonylureas,
Insulin 
Very infrequently:
Metformin,
GLP-receptor agonists,
SGLT-2, and 
DPP-4 inhibitor

Hypoglycemia In Non-Diabetics:
Hormonal dysfunction             
Addison's disease
Hypopituitarism
Non-B cell tumors.
Post-gastric bypass
Insulinomas.
Drugs: 
NSAID’s, phenylbutazone, propoxyphene,  
Quinine 
Lithium, TCA, chlorpromazine,   
Fluoxetine, sertraline,
ACE-inhibitors, arbs, beta-blockers.
Levofloxacin, trimethoprim-sulfamethoxazole, 
Mifepristone, 
Heparin
Mercaptopurine.
Haloperidol, pentamidine, 
Disopyramide, 
isoniazid, methotrexate, 
fenfluramine, thiazide diuretics,        
Opioid analgesic tramadol.

                                                          

 

  • Pyogenic abscess, accounts for 80% of abscess.
  • Amebic abscess due to Entamoeba histolytica, accounts for 10%.
  • Fungal abscess, accounts for < 10%.
  • 50% of solitary liver abscesses occur in the right Liver lobe.
  • Right hepatic lobe (~75%), less commonly left (20%) or caudate (5%) lobes.
  • Pyogenic abscesses are usually polymicrobial.
  • 50% of the bacterial cases develop by cholangitis. 
  • Pyogenic Abscess- initial manifestation of an occult intra‐abdominal malignancy (up to 15%).
  • Positive blood cultures in up to 50%.
  • Most common organisms: E. coli, Klebsiella, Streptococcus, Staphylococcus, & anaerobes.
  • K pneumoniae thought to be associated with colorectal cancer.
  • Fever in 90% & abdominal pain in about 50-75%.
  • In-hospital mortality estimated at 2.5% -19%

       Drainage of the abscess & antibiotic treatment are the cornerstones of treatment.

  • Antibiotic Therapy: 
        If the size of the abscess < 3-5 cm
        Oral antibiotics are given after intravenous antibiotics are first administered. 
  • Percutaneous Drainage: 
         Abscess > 5 cm
         Continuous fever despite 48-72 hours of ABX therapy
         Indications that the abscess may rupture
         U/S or CT-guided aspiration & drainage- first-line treatment. 
  • Surgery:
          Where percutaneous drainage is impractical.
          When there are complications like rupture or numerous abscesses. 
          Open surgery or laparoscopic surgery.



Significant electrolyte depletion can result in serious complications. These guidelines are meant to assist with empiric dosing of electrolytes for inpatients. Doses may need to be adjusted based on patient-specific factors, including creatine & cardiac status; & responses to initial doses.

  • Goal serum potassium concentration 4.0 – 5.0 mEq/L
  • Goal serum ionized calcium concentration 1.12 – 1.3 mmol/L
  • Goal serum magnesium concentration 2.0 – 2.4 mg/dL
  • Goal serum phosphorus concentration 2.7 – 4.6 mg/dL

IV electrolyte replacement can produce life-threatening complications, serious arrhythmias & phlebitis; therefore, supplementation must be carefully monitored.  There are multiple underlying factors for electrolyte disorders in adult inpatients, including alterations in absorption, distribution, hormonal, and/or homeostatic mechanisms that can all cause disturbances. Treating the underlying cause and prescribing adequate therapy is essential for repletion. In addition, the intracellular vs. extracellular electrolyte concentrations must be considered. Due to distribution variances, labs may not directly correlate with true electrolyte levels. Therefore, continuous monitoring is essential to properly replete patients.

 


A systematic approach to the analysis of the fluid in conjunction with the clinical presentation helps to understand the etiology, narrow the differential diagnoses, & design a management plan. Includes biochemistry, microscopic examinations & infectious disease tests.


 

 Chronic, constantly progressive disease. Initially, it affects the muscle tissues of the face, then spreads to the trunk. The following types of MG are distinguished:
  • Ocular – the nerve endings in the cranial region are affected, and the eyelids fall asymmetrically. The patient complains of double vision and deterioration in visual acuity. Gradually focusing on one subject becomes difficult.
  • Bulbar – the lesion extends to the masticatory muscles and tissues of the larynx. The patient’s voice changes, speech becomes quieter and nasal. Some consonants are very difficult to pronounce, and stuttering develops. Due to the penetration of fluid into the respiratory tract, the risk of pneumonia increases.
  • Lambert-Eaton – the muscles of the arms, legs, and neck do not receive nerve impulses. It is difficult for the patient to coordinate these areas of the body. This form is diagnosed in the elderly and is characterized by rapid progression.
  • Generalized – the muscles of the eyes are immediately affected, then the process spreads to the larynx, arms, legs, and hips. The main danger of this form is that the respiratory muscles are affected over time.
The disease is characterized by constant progression. 

Plasma exchange (PLEX) is first-line for severe exacerbation & usually causes improvement in a few days. It directly removes anti-acetylcholine receptor antibody from the body. May be more effective in MuSK+ patients.

IVIG may be useful for less severe exacerbations; takes longer to work (e.g., 2-3 weeks), but the efficacy may be more sustained. The dose of IVIG is 2 grams/kg, usually divided over 2 or 5 days.


  1. Immune-mediated: Some drugs can trigger an immune response in the body, leading to the production of antibodies that attack and destroy platelets. This immune-mediated destruction of platelets is one of the common mechanisms in drug-induced thrombocytopenia. Examples of drugs associated with immune-mediated DITP include certain antibiotics (such as penicillin and sulfonamides), anti-inflammatory drugs (such as nonsteroidal anti-inflammatory drugs, or NSAIDs), and anticonvulsants.

  2. Non-immune-mediated: Other drugs can cause thrombocytopenia through non-immune mechanisms, such as direct toxicity to the bone marrow where platelets are produced. Chemotherapy drugs, for example, can suppress bone marrow function and lead to a decrease in platelet production.

Average arterial pressure throughout one cardiac cycle, systole, and diastole. 
Surrogate indicator of blood flow and believed to be a better indicator of tissue perfusion.
To perfuse vital organs requires the maintenance of a minimum MAP of 60 mmHg. 
MAP = [Cardiac Output (CO) x Systemic Vascular Resistance (SVR)] + Central Venous Pressure (CVP)
MAP = (CO × SVR) + CVP
Because CVP is usually at or near 0 mmHg, this relationship is often simplified to:
MAP ≈ CO × SVR.
Cardiac output (CO) = Heart Rate (HR) X Stroke Volume (SV).

Stroke Volume is by ventricular inotropy and preload. 
Preload is affected by blood volume and the compliance of veins. 
Increasing the blood volume increases the preload, increasing the stroke volume and therefore increasing cardiac output. 
Afterload also affects the stroke volume in that an increase in afterload will decrease stroke volume. 
Heart rate is affected by the chronotropy, dromotropy, and lusitropy of the myocardium. 
Systemic vascular resistance is determined primarily by the radius of the blood vessels. 
Decreasing the radius of the vessels increases vascular resistance. 
Increasing the radius of the vessels would have the opposite effect. 
Blood viscosity can also affect systemic vascular resistance. 
An increase in hematocrit will increase blood viscosity and increase systemic vascular resistance. 
Viscosity, however, is considered only to play a minor role in systemic vascular resistance.


Common formula:
MAP = Diastolic blood pressure + 1/3 (Systolic Blood pressure – Diastolic Blood Pressure)
          = DBP + 1/3(SBP – DBP) or 
MAP = DBP + 1/3(Pulse Pressure)
MAP = [Systolic Blood Pressure + (2 x Diastolic Blood Pressure)]
                                                      3
Example, if blood pressure is 82 mm Hg/50 mm Hg,

MAP = SBP + 2 (DBP) = 82 +2 (50) = 182 = 60.67 mmHg; or
                3                              3              3
MAP = 1/3 (SBP – DBP) + DBP = 1/3 (82-50) + 50 = 10.67 + 50 = 60.67 mmHg


In sepsis, vasopressors are often titrated based on the MAP. 
In the guidelines of the Surviving Sepsis Campaign, it is recommended that MAP be maintained ≥ 65 mm Hg.

Chronotropy = Heart Rate
Dromotropy = Speed of electrical conduction in the Heart
Lusitropy = Rate of myocardial relaxation
Inotropy = Contractility

Mean Arterial Pressure (MAP) = 70-100 mmHg

Cardiac Index (CI) = Cardiac Output (CO)/ Body Surface Area (BSA) 
                               = 2.5-4 L/min/m2.

Stroke volume (SV) = Cardiac output / Heart Rate 
                                 = 60-120 mL/beat.

Systemic vascular resistance (SVR) = (MAP – Mean Right Atrial Pressure) x 80 / CO 
                                                          = 800-1200 dynes x sec/cm3.
Pulmonary Vascular Resistance = (Mean Pulmonary Artery Pressure – Mean Pulmonary Capillary Wedge Pressure) X 80 / Cardiac Output 
                                                 =125-250 dynes X sec/cm3.


Pulse Pressure (PP)
Pulse Pressure (PP) = Systolic Blood Pressure – Diastolic Blood Pressure
Normal pulse pressure, approximately 40 mmHg.
Change in pulse pressure (Delta Pp) = Volume change (Delta-V) = Stroke volume (SV)
                                                                 Arterial compliance (C)     Arterial compliance (C)
                                                                         
                                                            = Approximately 80 mL = Approximately 40 mm Hg
                                                                       2 mL/mm Hg
Arterial compliance (C) = Delta V/Delta P
Because the aorta is the most compliant portion of the human arterial system, the pulse pressure is the lowest. Compliance progressively decreases until it reaches a minimum in the femoral and saphenous arteries, and then it begins to increase again. 

Narrowed PP (Low) < 25% of the SBP.
Widened PP (High) > 100 % of SBP.

Widened (High) Pulse Pressure (PP)
> 100 % of SBP
Indicative of a noncompliant stiff aorta with a reduced ability to distend and recoil.
With age there is a decrease in compliance of the aorta & small arteries.
In majority, SBP increase while DBP remain near normal. 
In aortic regurgitation (AR), backward, or regurgitant flow, increase SBP and decrease DBP, and therefore increased PP.
Heart valve conditions (Aortic regurgitation, Aortic sclerosis)
Reduced blood viscosity (Severe Iron deficiency anemia)
Increased systolic pressure (Hyperthyroidism), 
Less compliant arteries (Arteriosclerosis)

Narrow (Low) Pulse Pressures (PP)
< 25% of the SBP
Decreased pumping (Heart failure), 
Decreased Stroke Volume (Aortic Stenosis)
Decreased Blood Volume (Blood loss), 
Decreased Filling Time (Cardiac Tamponade/Pericarditis). 
Dysautonomia/postural orthostatic tachycardia syndrome (POTS)

  • RA-associated interstitial lung disease (RA-ILD).
  • Pleural disease (pleural thickening/effusions).
  • Airway disease (Both upper & lower airway).
  • Rheumatoid nodules
  • Drug-induced lung toxicity (i.e., Methotrexate-induced lung injury)
  • Fibro-bullous disease
  • Thoracic cage immobility
  • Venous thromboembolic disease
  • Vasculitis
  • Pneumonia.
RHEUMATOID EFFUSION:
  • WCC <5000/mm3
  • Fluid glucose <60 mg/Dl
  • Pleural fluid to serum glucose ratio < 0.5
  • pH < 7.3
  • High pleural LDH level (ie, > 700 IU/L)
  • Cytology: Slender or elongated multinucleated macrophages, round giant multinucleated macrophages, and necrotic background debris.
Pulmonary function testing in ILD (PFT):
  • Reduced VC, lung volumes, & DLCO.
  • Oxygen desaturation during exercise.
  • Restrictive abnormalities common (poor muscle strength or kyphosis due to osteoporosis rather than ILD).


 

  • Indicator of kidney damage and / or a biomarker of systemic diseases dates back to 1969, when elevated albumin levels were first demonstrated in the urine of patients with newly diagnosed diabetes.
  • Urine dipstick is a relatively insensitive marker for albuminuria, not becoming positive until albumin excretion exceeds 300-500 mg/day. 
  • Normal rate of albumin excretion is < 30 mg/day (20 mcg/min).
  • Persistent albumin excretion between 30-300 mg/day (20 to 200 mcg/min) is called moderately increased albuminuria (formerly called "microalbuminuria").
  • Excretion > 300 mg/day (200 mcg/min) represents overt or dipstick positive proteinuria (severely increased albuminuria [formerly called "macroalbuminuria"].
  • Albuminuria reflects functional and / or structural changes in the glomerular filtration membrane that allow increased leakage of albumin into primary urine in amounts exceeding the reabsorption capacity of the proximal nephron tubules. 
  • Albuminuria considered as an indicator of early damage (dysfunction) of the vascular endothelium (including the glomerular vessels), which leads to increased permeability of the vascular wall. 
  • Relationship between albuminuria and cardiovascular risk has been shown in studies of the general population. 
  • It is linear and risk is independent of eGFR. 
  • Associated with arterial stiffness assessed by the pulse wave velocity measurement







  • Cytoplasmic enzymes present in tissues throughout the body.
  • Oxidoreductase, enzyme of the anaerobic metabolic pathway.
  • Heart, muscle, kidney, lung, and RBC’s have the highest concentration.
  • Upon tissue damage, the cells release LDH in the bloodstream.
  • Drugs that can increase LDH include alcohol, aspirin, fluorides, narcotics, anesthetics, clofibrate, mithramycin, and procainamide.
  • Cancer cells employ LDH to increase their aerobic metabolism (glycolysis, ATP production, & lactate production): Warburg effect.
  • CSF LDH increases in bacterial meningitis (normal in viral meningitis).
  • Cancer cells undergo LDH mediated energy production to fulfill the demand for fast cellular growth (marker of metastases, prognosis, survival rates., and radiosensitivity).
  • LDH serves as a general indicator of acute and chronic diseases.
  • LDH helps in distinguishing exudate from transudate effusions.
  • Isozymes, named LDH-1 through LDH-5, have differential expression in different tissues.

 

Role of Bile acids

  • Bile acids play a key role in the absorption of lipids in the small intestine. 
  • Contribute to cholesterol metabolism by promoting the excretion of cholesterol. 
  • Denature dietary proteins, thereby accelerating their breakdown by pancreatic proteases. 
  • Direct and indirect antimicrobial effects. In this capacity, recent evidence suggests bile acids are mediators of high-fat diet-induced changes in the gut microbiota. 
  • Act as signaling molecules outside of the gastrointestinal tract.

The primary bile acids—cholic acid and cheno-deoxycholic acid—are synthesized from cholesterol in the liver.

The maximal rate of bile acid synthesis is on the order of 4 to 6 g/day.



Horseshoe kidneys are often asymptomatic with incidence of approximately 1 in 500 in the normal population with a male preponderance of 2:1.

The isthmus connecting the two renal masses may be positioned in the midline or laterally resulting in an asymmetric horseshoe kidney, 70% of which are left dominant.

The isthmus consists of renal parenchyma in about 80% of cases with the remainder being composed of a fibrous band.

In more than 90% of cases, fusion occurs at the lower pole, although fusion may occur at the upper pole in a small minority of cases.

Higher incidence of UPJ obstructions, nephrolithiasis, and reflux compared to the general population. Increased frequency of some common renal cancers including transitional cell tumors (three to four times more common), Wilms tumor (twice as frequently), and an extremely large increase in very rare tumors such as carcinoid (62 to 82 times).






Autosomal Dominant, M = F, by 60 yrs-50% need renal replacement therapy

Multisystem & progressive disease with cysts formation

Kidney enlargement with other organ involvement (liver∼ 80%, pancreas 7-36%, spleen)

Intracranial aneurysms in ∼6% of pts without family history & ∼20% with a family history (rupture in 65-75%, usually before age 50)

Cardiac Valve abnormalities in 25-30%








  • First sensation of bladder filling at 100–150ml in an adult.
  • Feeling of need to pee at 200 - 350 ml of urine
  • Can comfortably hold between 300 - 450 ml
  • Wall pressure of 5 - 15 mm Hg creates a sensation of bladder fullness while 30 mm Hg & beyond is painful.
  • Most people pee 6 or 7 times/ 24 hours (4 -10 times daily is healthy).
  • Normal 24-hour Urine output is 800 - 2000 ml/day (at normal fluid intake of about 2 liters/day).





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