Menu

Warfarin induced skin necrosis

Warfarin induced skin necrosis is often heralded by paresthesia, or a sensation of pressure, associated with an erythematous flush that is usually poorly demarcated. The lesions are painful, sudden, well localized and initially hemorrhagic or erythematous. In women, the site of the lesion is random and unpredictable, but the breast is the most common site, followed by the buttocks and thighs. Occasionally, the trunk, face and extremities are also involved.

The mechanism is thought to be that, following the initiation of warfarin, both protein C antigen and activity levels drop rapidly, compared with levels of other vitamin K-dependent factors such as factors IX and X, and prothrombin. This observed rapid early fall in protein C level prompted the hypothesis that the administration of warfarin to protein C-deficient individuals causes a temporary exaggeration of the imbalance between pro- coagulant and anticoagulant pathways; that is, the early suppressive action of warfarin on protein C may not be counterbalanced by the anticoagulant effect created by the decline in other vitamin K-dependent factors, thereby leading to a relative hypercoagulable state at the start of treatment. This leads to thrombotic occlusions of the microvasculature with resulting necrosis.

Disclaimer

The compendium of content enshrined within this website—including its lexical compositions, pictorial representations, and adjunctive materials—is exclusively proffered for erudition and cerebral enlightenment. Under no circumstances should it be erroneously construed as a surrogate for sagacious medical discernment or the perspicacious adjudication of a licensed clinician. This platform does not purvey medical counsel, nor should its corpus be invoked for nosological determinations, curative stratagems, or any consequential healthcare resolutions. The expositions delineated herein are solely the intellectual purview of the respective authors and do not, in any capacity, embody the official imprimatur of any affiliated entity. The textual articulations, iconographic embellishments, and graphical constituents are scrupulously curated from august scholarly treatises and publicly accessible epistemic repositories. Notwithstanding our indefatigable endeavors to perpetuate the unimpeachable accuracy and contemporaneity of the medical intelligence imparted, we cannot incontrovertibly guarantee its seamless congruence with the perpetually evolving corpus of scientific advancement. In exigent or dire exigencies, one must expeditiously summon emergency medical intervention by dialing 911. For individuated and bespoke medical advisement, it is imperative to solicit the sagacious counsel of a duly credentialed physician. Under no vicissitude should professional medical advisement be abnegated, procrastinated, or supplanted by perusals of this website’s contents. Moreover, this platform neither extols nor promulgates particular nosological postulations, medical functionaries, remedial methodologies, pharmacological conglomerates, or doctrinaire therapeutic philosophies. By availing oneself of this website’s contents, the onus of securing veritable and authoritative medical counsel remains incontrovertibly vested in you. The website and its progenitors categorically repudiate any liability emergent from the construal, reliance upon, or extrapolation of its textual or visual constituents.

Search This Site

Copy Right @DharSaty

'O' My Dear LORD! Lead us, guide us, inspire us, and remind us to believe in possibilities.