Menu

Hematology Algorithms

Hematology Algorithms 

Anemia is described as a reduction in the proportion of the red blood cells. Most patients experience some symptoms related to anemia when the hemoglobin drops below 7.0 g/dL. RBC are produced in the bone marrow and released into circulation. Approximately 1% of RBC are removed from circulation per day. Imbalance in production to removal or destruction of RBC leads to anemia. 

The etiology of anemia depends on whether the anemia is hypo-proliferative (i.e., corrected reticulocyte count <2%) or hyperproliferative (i.e., corrected reticulocyte count >2%).  Hypo-proliferative anemias are further divided by the mean corpuscular volume into microcytic anemia (MCV<80 fl), normocytic anemia (MCV 80-100 fl) & macrocytic anemia (MCV>100 fl). 

Pancytopenia is a hematologic condition characterized by a decrease in all three peripheral blood cell lines. It is characterized by the hemoglobin of less than 12 g/dL in women and 13 g/dL in men, platelets of less than 150,000 per mcL, and leukocytes of less than 4000 per ml (or absolute neutrophil count of less than 1800 per ml). However, these thresholds largely dependent on age, sex, race as well as varying clinical scenarios. 

Leukopenia is primarily seen as neutropenia since neutrophils constitute the majority of the leukocytes. The etiology of pancytopenia can be broadly categorized as a central type that involves production disorders or a peripheral type that involves disorders of increased destruction. These causes could contribute to the pancytopenia independently or as a combination. 

Red cell distribution width (RDW) = (standard deviation of MCV/mean MCV) × 100. 

Normal range11.5–14.5% has suspicion of thalassemia trait & high often indicates IDA 

Mentzer index = (MCV/RBC count). 

< 13 may represent thalassemia trait & >13 often indicates IDA


Disclaimer

The compendium of content enshrined within this website—including its lexical compositions, pictorial representations, and adjunctive materials—is exclusively proffered for erudition and cerebral enlightenment. Under no circumstances should it be erroneously construed as a surrogate for sagacious medical discernment or the perspicacious adjudication of a licensed clinician. This platform does not purvey medical counsel, nor should its corpus be invoked for nosological determinations, curative stratagems, or any consequential healthcare resolutions. The expositions delineated herein are solely the intellectual purview of the respective authors and do not, in any capacity, embody the official imprimatur of any affiliated entity. The textual articulations, iconographic embellishments, and graphical constituents are scrupulously curated from august scholarly treatises and publicly accessible epistemic repositories. Notwithstanding our indefatigable endeavors to perpetuate the unimpeachable accuracy and contemporaneity of the medical intelligence imparted, we cannot incontrovertibly guarantee its seamless congruence with the perpetually evolving corpus of scientific advancement. In exigent or dire exigencies, one must expeditiously summon emergency medical intervention by dialing 911. For individuated and bespoke medical advisement, it is imperative to solicit the sagacious counsel of a duly credentialed physician. Under no vicissitude should professional medical advisement be abnegated, procrastinated, or supplanted by perusals of this website’s contents. Moreover, this platform neither extols nor promulgates particular nosological postulations, medical functionaries, remedial methodologies, pharmacological conglomerates, or doctrinaire therapeutic philosophies. By availing oneself of this website’s contents, the onus of securing veritable and authoritative medical counsel remains incontrovertibly vested in you. The website and its progenitors categorically repudiate any liability emergent from the construal, reliance upon, or extrapolation of its textual or visual constituents.

Search This Site

Copy Right @DharSaty

'O' My Dear LORD! Lead us, guide us, inspire us, and remind us to believe in possibilities.